相关实验视频
Updated: Aug 19, 2026

09:45
An Isolated Working Heart System for Large Animal Models
Published on: June 11, 2014
概括
这项研究揭示了单心室和L转位的心脏中的辅助心房 (A-V) 节点,这对于形成His.的捆绑至关重要. 了解这种导电系统对于手术干预至关重要.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 心脏解剖学 心脏解剖学
背景情况:
- 先天性心脏缺陷,包括单心室和L转移,存在复杂的解剖学挑战.
- 这些心脏中的导电系统的解剖学尚未完全理解,这会影响手术的结果.
研究的目的:
- 为了阐明心脏导电系统的详细解剖学,心脏单心室和反向L-循环转换.
- 确定关键的解剖学里程碑,与手术规划和降低风险相关.
主要方法:
- 三个心脏的连续切割,单心室和反转的L转移.
- 详细组织学检查心室 (A-V) 节点和希斯-普尔金耶系统.
主要成果:
- 观察到一个基本的后部A-V节点,不形成His.的捆绑.
- 一个附属的前面AV节点被确定,导致了His.的捆绑.
- 他的捆绑在主腹腔室内分为两部分,有明显的右和左捆绑分支.
- 一个案例显示前节点分裂,一个部分形成His束,另一个发出Mahaim纤维.
结论:
- 带有L转位的单心室导电系统起源于一个附属的前部AV节点.
- 手术方法必须小心避免肺结节的右侧和隔膜缺陷区域.
- 详细的解剖学知识对于在纠正手术期间预防导电异常至关重要.
相关概念视频
The Cardiac Cycle
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
Conduction System of the Heart
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
Development of the Heart
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
Conduction System of the Heart
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
This system relies on the unique properties of nodal and Purkinje cells:...

