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相关概念视频

Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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相关实验视频

Updated: Jul 13, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

基因和干细胞治疗方法

E H Kaji1, J M Leiden

  • 1Abbott Laboratories, Department of Executive, Bldg AP6D, 100 Abbott Park Rd, Abbott Park, IL 60064, USA.

JAMA
|February 15, 2001
PubMed
概括

基因和干细胞疗法为遗传性和获得性疾病提供了潜在的治疗方法. 进一步研究载体开发,干细胞生物学和伦理考虑对于实现它们的全部治疗承诺至关重要.

科学领域:

  • 生物医学科学 生物医学科学
  • 再生医学是一种再生医学.
  • 分子生物学分子生物学

背景情况:

  • 基因和干细胞疗法在治疗各种人类疾病方面表现有前途.
  • 通过基因鉴定和新型传递载体,基因疗法取得了重大进展.
  • 干细胞研究随着干细胞可塑性的发现和人类胚胎干细胞的创造而取得进展.

研究的目的:

  • 审查基因和干细胞疗法的进展和潜力.
  • 突出基因鉴定,载体开发,干细胞隔离和可塑性方面的进展.
  • 要强调该领域的剩余挑战和伦理考虑.

主要方法:

  • 关于基因和干细胞疗法的当前文献的综述.
  • 分析基因鉴定和基因治疗载体开发的进展情况.
  • 对干细胞隔离,可塑性和治疗可行性的检查.

主要成果:

  • 基因治疗由于改进的基因识别和传递系统而取得了进展.
  • 干细胞疗法是可行的,得到了干细胞可塑性和人类胚胎干细胞创造方面的发现的支持.
  • 在载体发育和干细胞生物学方面仍有大量的工作.
关键词:
生物医学和行为研究研究.遗传学和生殖生殖学

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Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
11:16

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
08:32

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications

Published on: August 9, 2022

相关实验视频

Last Updated: Jul 13, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
11:16

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
08:32

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications

Published on: August 9, 2022

结论:

  • 基因和干细胞疗法在治疗各种疾病方面具有相当大的前景.
  • 为了克服载体开发和干细胞生物学方面的技术挑战,进一步的研究是必不可少的.
  • 围绕这些先进疗法的伦理问题需要仔细考虑和讨论.