用维生素B补充异构性饮食并不能预防子中的动脉样硬化或血管功能障碍
S R Lentz1, D J Piegors, M R Malinow
1Veterans Affairs Medical Center, Departments of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA. steven-lentz@uiowa.edu
Circulation
|February 22, 2001
概括
维生素B补充剂有效地防止子的高水平的同型半氨酸. 然而,它们不能防止血管功能障碍或动脉样硬化,即使高胆固醇.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 血管生物学 血管生物学
背景情况:
- 过高homocysteinemia是动脉样硬化和血栓性血管疾病的已知危险因素.
- 食补充维生素B是一种潜在的策略来管理高血糖质血症.
- 维生素B在预防血管疾病方面的临床疗效尚未得到证实.
研究的目的:
- 调查B族维生素补充剂是否可以预防高血糖血症,血管功能障碍和动脉样硬化在接受动脉样饮食的子中.
- 在灵长类动物模型中确定维生素B对血管健康标记物的影响.
- 评估B族维生素在减轻饮食引起的血管病理方面的足够性.
主要方法:
- 子被养以异质性饮食,其中一组接受B族维生素补充剂 (叶酸,B12,B6) 和对照组不接受补充剂.
- 在17个月后测量了血homocysteine和血清胆固醇水平.
- 通过测量对内皮依赖性血管扩展剂的反应来评估血管功能 in vivo 和 ex vivo.
- 在主要动脉中评估了动脉样硬化病变的发展,特别是内脏变厚.
主要成果:
- 维生素B补充剂成功地防止了血类固醇水平的上升.
- 补充和不补充的两组都显示血清胆固醇的显著增加.
- 通过血管扩张反应评估的血管功能障碍和抗凝剂反应在两组中同样受到损害.
- 维生素补充剂并不能防止心脏动脉或门动脉的内密加厚.
结论:
- 在这种灵长类动物模型中,食B族维生素有效地预防了高血糖蛋白质血症.
- 单独补充维生素B是不足以防止血管功能障碍和动脉样硬化在存在明显的高胆固醇血症.
- 这些发现突出了同类半素,胆固醇和血管健康之间的复杂相互作用,表明维生素B可能不是预防饮食引起的血管疾病的独立解决方案.
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