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相关概念视频

Redox Reactions01:24

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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相关实验视频

Updated: Jul 17, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

在患有青少年性皮肤肌炎的儿童中,化学反应.

A M Reed, Y J Picornell, A Harwood

    Lancet (London, England)
    |February 24, 2001
    PubMed
    概括

    在大多数患有青少年性皮肤肌炎的儿童中,发现了化学性,即存在两个不同的细胞群. 这一发现表明,嵌合体和自身免疫性疾病之间存在潜在的联系.

    科学领域:

    • 儿科风湿病学 儿科风湿病学
    • 免疫学 免疫学 免疫学
    • 遗传学 是一个遗传学.

    背景情况:

    • 青少年皮肤肌肉炎 (JDM) 与慢性移植对宿主疾病具有临床相似之处.
    • 嵌合体在JDM病变发生过程中的潜在作用在很大程度上仍未被探索.

    研究的目的:

    • 调查被诊断患有青少年性皮肤肌炎的儿童中奇默症的存在和程度.

    主要方法:

    • 用聚合酶连锁反应 (PCR) 来检测仿真.
    • 分析包括外周血液单核细胞和肌肉组织样本.
    • 对照组由兄弟姐妹和不受影响的对照组组成.

    主要成果:

    • 在15名患有JDM的儿童中,在13名儿童中检测到化学反应.
    • 在11/15的JDM患者的外周血液中和12/15的肌肉组织中发现了母细胞.
    • 与兄弟姐妹和对照人群相比,在JDM患者中观察到显著更高的嵌合体率 (p<0.0001).

    结论:

    • 这些发现强烈地表明,嵌合体和青少年皮肤肌炎之间存在显著的关联.
    • 化学反应,特别是母细胞微化学反应,可能是导致JDM发展或进展的因素.

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