在移植和血管排斥后,内皮细胞化
E L Lagaaij1, G F Cramer-Knijnenburg, F J van Kemenade
1Department of Pathology, Leiden University Medical Centre, The Netherlands. Lagaay.vaneyck@wxs.nl
Lancet (London, England)
|February 24, 2001
概括
受体内皮细胞可以在移植脏中取代供体细胞,这与移植体排斥有关. 这一发现表明了对移植免疫学和预防排斥的潜在治疗点的新理解.
科学领域:
- 移植免疫学 移植免疫学
- 血管生物学 血管生物学
- 腎臟移植 腎臟移植
背景情况:
- 血管是器官移植中的关键接口.
- 内皮是移植排斥的主要目标.
- 据推测,捐赠者的内皮细胞在移植后仍然存在.
研究的目的:
- 为了研究移植脏移植中的内皮细胞的起源.
- 为了确定移植后是否存在受体衍生的内皮细胞.
- 评估受体内皮细胞与移植体排斥之间的相关性.
主要方法:
- 对移植活检样本的分析.
- 使用免疫组织化学 (MHC类-I,ABO血型抗原) 和in-situ杂交 (X和Y染色体).
- 在26名患者中,接受者内皮细胞的存在与移植拒绝状态相关联.
主要成果:
- 在接受者内皮细胞百分比和移植体排斥之间发现了强烈的相关性 (r = 0.71,p < 0.0001).
- 受体内皮细胞主要在经历排斥的移植中发现,特别是血管排斥.
- 没有排斥的移植仅偶尔检测到受体内皮细胞.
结论:
- 受体内皮细胞确实可以在移植脏中取代来自捐赠者的内皮细胞.
- 受体内皮细胞的存在与移植体排斥有显著的关联.
- 假设在血管排斥过程中受损的内皮被受体内皮细胞修复.
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