在对盐敏感高血压中,通过盐调节血内甲蛋白
F Elijovich1, C L Laffer, E Amador
1Section of Hypertension, University of Texas Medical Branch at Galveston, USA. Fernando_Elijovich@grmerc.net
Circulation
|February 24, 2001
概括
在高血压患者中,较高的内甲素水平与盐敏感性有关. 缺乏盐分,对盐分敏感的个体表现出catecholamine刺激的内甲蛋白增加,这表明内甲蛋白受体抑制剂的潜在益处.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 高血压研究 高血压研究
背景情况:
- 在实验性高血压模型中,依赖盐的血压调节至关重要.
- 内膜蛋白是重要的血管收缩剂,但它们在人类高血压中的盐平衡调节尚未得到充分研究.
研究的目的:
- 为了研究人体基本高血压中盐平衡对血内甲蛋白的调节.
- 探索盐敏感性,内甲蛋白,甲醇胺和血仁素活性 (PRA) 之间的关系.
主要方法:
- 在47名高血压患者和20名对照组中测量了血内甲蛋白.
- 在29名患者中评估了24小时剥夺后的内甲素,甲醇胺和PRA反应.
- 根据血压对降低的反应,将患者分为敏感盐,耐盐和不确定的组.
主要成果:
- 高血压患者的基线内甲素比对照人群高,与血压相关,与PRA相反.
- 对盐敏感的患者在缺乏后表现出淡的PRA反应和显著增加的甲基荷兰胺和内甲蛋白.
- 在缺乏盐的状态下,内啡素水平在盐敏感患者中最高,与catecholamine变化相关.
结论:
- 缺乏盐分的,对盐分敏感的高血压患者,表现出较低的氨酸反应,表现出由甲基荷胺刺激的内衣林水平升高.
- 这些发现表明,内甲素受体抑制剂可能在对盐敏感的高血压患者中更有效.
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