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患者和医生对干细胞移植成功的估计之间的差异

S J Lee¹, D Fairclough, J H Antin

¹Center for Outcomes and Policy Research, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA. stephanie_lee@dfci.harvard.edu

|March 7, 2001

概括

当结果有利时,患者和医生可以准确估计干细胞移植的风险. 然而,患有晚期疾病的患者往往对他们的预后过于乐观.

科学领域:

血液学血液学血液学
在瘤学瘤学.
移植医学移植医学

背景情况:

干细胞移植 (SCT) 具有重大风险,包括发病率和死亡率.
患者和医生对SCT风险感知的准确性尚未得到充分理解.

研究的目的:

评估患者和医生对SCT结果的期望.
为了将这些预期与实际的移植后结果相关联.

主要方法:

一项前性队列研究,涉及313名SCT患者及其医生.
基线调查问卷评估了对死亡率和治愈的预期.
随访数据分析了实际死亡率和无病生存率.

主要成果:

预期与死亡风险低于30%的结果一致.
对于高风险的SCT (例如,晚期疾病),医生低估了风险,而患者仍然乐观.
医生预测晚期疾病的生存率较低,与患者持久的乐观相反.

结论:

对于有利的SCT结果,患者和医生的预期是最准确的.
患有晚期疾病的患者往往低估了与他们特定情况相关的高风险.

关键词:

经验方法的实证方法.医疗保健和公共卫生

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