第二季度超声波检测患有唐氏综合征的胎儿:一个元分析
R Smith-Bindman1, W Hosmer, V A Feldstein
1Department of Radiology, University of California, San Francisco, 1600 Divisadero St, San Francisco, CA 94115, USA. Rebecca.Smith-Bindman@radiology.ucsf.edu
JAMA
|March 7, 2001
概括
唐氏综合征的第二季度超声波标记的准确性较低. 加厚的部折显示出一些希望,但对实际查来说没有足够的敏感性. 其他标记物对于检测唐氏综合征是不可靠的.
科学领域:
- 产前诊断 在产前诊断.
- 医学成像医学成像
- 遗传学 遗传学 是一个
背景情况:
- 第二个三个月的产前超声波是检测胎儿唐氏综合征的常见方法.
- 然而,这种查方法的诊断准确性仍然不清楚.
研究的目的:
- 评估第二个三个月的超声波标记在识别胎儿唐氏综合征时的准确性.
- 在产前查中评估特定超声波发现的有效性.
主要方法:
- 1980年至1999年2月出版的英语文章的系统审查.
- 包括56项研究,包括1930名被诊断患有唐氏综合征的胎儿和130,365名未受影响的胎儿.
- 计算了敏感度,特异性和概率比,用于标记物,如巴厚度,回声性心内焦点等.
主要成果:
- 超声波标记物,当隔离时,显示出对唐氏综合征检测的低灵敏度 (1% - 16%).
- 加厚的部折是最有效的标志物,增加了约17倍的唐氏综合征风险.
- 其他标志物,没有相关的发育不良,对唐氏综合征风险评估的影响很小.
结论:
- 加厚的部可能有助于区分唐氏综合征,但缺乏足够的灵敏度用于实际查.
- 孤立的超声波标记器在区分受影响和未受影响的胎儿方面不可靠.
- 依靠这些标记物来做出羊水切割决定可能会导致胎儿损失比检测到的唐氏综合征病例更多.
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