针对晚期雄激素独立前列腺癌的骨向治疗:一个随机的II期试验
S M Tu1, R E Millikan, B Mengistu
1Department of Genitourinary Medical Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA. stu@notes.mdacc.tmc.edu
Lancet (London, England)
|February 24, 2001
概括
将-89 (Sr-89) 添加到多克索鲁比辛化疗中,显著改善了骨转移的晚期前列腺癌患者的存活率. 与单独使用多克索鲁比辛相比,这种针对骨的治疗可以减少疼痛并延长寿命.
科学领域:
- 在瘤学瘤学.
- 放射性药物疗法是一种放射性药物疗法.
背景情况:
- 前列腺癌经常转移到骨,导致骨质细胞损伤.
- 先进的雄激素独立前列腺癌存在重大治疗挑战.
研究的目的:
- 评估骨针对性巩固治疗在患有晚期前列腺癌和骨转移的患者中的疗效.
- 评估-89 (Sr-89) 与多克索鲁比辛结合对生存和疼痛缓解的影响.
主要方法:
- 103名患者接受了基托可纳,多克索鲁比辛,エスト拉穆斯和文布拉斯的诱导化疗.
- 72名患者被随机分配,接受6周的多克索鲁比辛与或没有Sr-89.
- 血清前列腺特异性抗原 (PSA) 水平和骨头疼痛受到监测.
主要成果:
- 在60%的患者中观察到50%或更大的PSA减少;42%的患者有80%或更大的减少.
- 52%的骨疼痛患者实现了完全的疼痛缓解.
- 服用Sr-89加 doxorubicin 的中位生存时间为27.7个月,仅服用 doxorubicin 的中位生存时间为16.8个月 (p=0.0014).
结论:
- 用Sr-89和多克索鲁比辛针对骨的巩固疗法改善了晚期前列腺癌的整体存活率.
- 这种方案为诱导化疗后疾病稳定或反应良好的患者提供了有价值的选择.
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