在HIV/HCV共感染的里巴维林中,线粒体毒性增加
Lancet (London, England)
|February 24, 2001
概括
用利巴维林和干扰素α治疗C型肝炎可能会导致艾滋病毒共感染患者的严重线粒体毒性,特别是那些接受核类比疗法的患者. 这种药物相互作用可能会导致多器官功能障碍和乳酸化.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 与人类免疫缺陷病毒 (HIV) 和C型肝炎病毒 (HCV) 共同感染是常见的.
- 高活性抗逆转录病毒疗法 (HAART) 是艾滋病毒管理的标准.
- 干扰素-阿尔法加利巴维林是一种治疗HCV的药物.
研究的目的:
- 调查结合型肝炎和艾滋病毒治疗的潜在不良影响.
- 评估HIV感染患者接受特定抗病毒疗法的线粒体毒性风险.
主要方法:
- 这是一项对15名同时感染HIV和HCV的患者的观察性研究.
- 患者除了接受高活性抗逆转录病毒疗法 (HAART) 之外,还接受了干扰素α加上里巴维林.
- 监测不良事件,包括多器官功能障碍和乳酸血症.
主要成果:
- 15名患者中有2名患有多器官功能障碍和乳酸血症.
- 核类比物利巴维林 (ribavirin) 被认为是毒性的潜在原因.
- 这种毒性风险在已经接受核酸类比治疗的HIV患者中增加.
结论:
- 与干扰素α,利巴维林和HAART联合治疗有严重不良事件的风险.
- 由于核糖类模拟相互作用的线粒体毒性是 coinfected 患者的一个重大问题.
- 临床恶化可能发生,需要仔细监测患者.
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