Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Analysis of power law fluid for nutritional transport in the human capillary.

Computers in biology and medicine·2026
Same author

Unified Gait Event Detection using Temporal Convolutional Network and Bayesian Optimization.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Feasibility of a perioperative smartphone application in colorectal surgery.

The British journal of surgery·2021
Same author

Flow analysis of Carreau fluid model induced by the ciliary cells, smooth muscle cells and pressure gradient at the ampullar region entrance.

Theory in biosciences = Theorie in den Biowissenschaften·2021
Same author

Antiviral activities of Cholistani plants against common poultry viruses.

Tropical biomedicine·2021
Same author

Comparison effectiveness of acute coronary syndrome treatments on geriatric function.

Annales de cardiologie et d'angeiologie·2020
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
查看所有相关文章

相关实验视频

Updated: Jun 29, 2026

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

谨慎标志着利用基因组的前景.

H Ashraf

    Lancet (London, England)
    |March 7, 2001
    PubMed
    概括

    No abstract available in PubMed .

    更多相关视频

    A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization
    08:20

    A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization

    Published on: September 2, 2021

    CIRCLE-Seq for Interrogation of Off-Target Gene Editing
    08:23

    CIRCLE-Seq for Interrogation of Off-Target Gene Editing

    Published on: November 1, 2024

    相关实验视频

    Last Updated: Jun 29, 2026

    Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
    07:55

    Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

    Published on: May 31, 2011

    A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization
    08:20

    A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization

    Published on: September 2, 2021

    CIRCLE-Seq for Interrogation of Off-Target Gene Editing
    08:23

    CIRCLE-Seq for Interrogation of Off-Target Gene Editing

    Published on: November 1, 2024