相关实验视频
Updated: Jun 28, 2026

20:16
Detecting Anastasis In Vivo by CaspaseTracker Biosensor
Published on: February 1, 2018
炎症和癌症:回到维尔肖的观点
1ICRF Translational Oncology Laboratory, St Bartholomew's and Royal London School of Medicine and Dentistry, UK. f.balkwill@icrf.icnet.uk
Lancet (London, England)
|March 7, 2001
概括
癌症的进展与炎症和伤口愈合有相似之处. 针对炎症途径和细胞因子显示出癌症预防和治疗的前景,提供新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 炎症研究 炎症研究
背景情况:
- 癌症反应机制与炎症和伤口愈合重叠.
- 瘤内的炎症细胞和细胞因子可能促进癌症生长和免疫抑制.
- 炎症性细胞因子基因的遗传变异可能会影响癌症的易感性和严重性.
研究的目的:
- 审查癌症和炎症之间的复杂联系.
- 讨论这些联系对癌症预防和治疗策略的影响.
- 在恶性疾病中为向细胞因子和化学因子通路提供理由.
主要方法:
- 关于癌症,炎症和伤口愈合之间的关系的文献综述.
- 分析炎症细胞和细胞因子在瘤进展中的作用.
- 检查炎症性细胞因子基因中的遗传多态性.
- 审查涉及细胞因子/化学因子阻断和抗炎药物的治疗策略.
主要成果:
- 瘤中的炎症媒介通常促进瘤生长,进展和免疫抑制.
- 抑制炎症性细胞因子已经证明在预防实验性癌症发展方面具有有效性.
- 细胞因子和化学因子抗剂,和瘤亡因子抗剂一样,在相关疾病中表现出临床疗效.
结论:
- 炎症可以作为癌症发展和进展的"燃料".
- 通过封锁准细胞因子和化学因子网络是癌症治疗和预防的可行策略.
- 对非类固醇抗炎药物的进一步研究对于化学预防和癌症治疗是有必要的.
相关概念视频
Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Classification of Illness
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
What is Cancer?
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

