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在加利福尼亚州,自闭症和MMR免疫覆盖率的时间趋势

L Dales¹, S J Hammer, N J Smith

¹Immunization Branch, California Department of Health Services, 2151 Berkeley Way, Room 712, Berkeley, CA 94704, USA. ldales@dhs.ca.gov

|March 20, 2001

概括

这项研究发现,麻疹--红疹 (MMR) 疫苗接种率与加利福尼亚儿童自闭症诊断之间没有联系. 尽管自闭症病例不断增加,但MMR免疫覆盖率显示变化很小,驳斥了因果关系.

科学领域:

儿科健康儿科健康
免疫学免疫学免疫学
发育神经科学的发展神经科学.

背景情况:

公众对麻疹-疹-红疹 (MMR) 疫苗接种与儿童自闭症率增加之间存在潜在联系表示担忧.
这一理论在医学界和世俗界引起了广泛的讨论.

研究的目的:

调查幼儿MMR免疫覆盖率趋势与自闭症发生之间的潜在相关性.
分析长期趋势,以确定疫苗接种率的变化是否与自闭症诊断的变化并行.

主要方法:

对1980年至1994年间在加利福尼亚州幼儿园出生儿童的MMR免疫记录的回顾性分析.
来自加利福尼亚州发育服务部的自闭症病例数据对相同的出生队列的审查.
根据出生年份对17个月和24个月的MMR免疫覆盖率和自闭症诊断之间的相关性分析.

主要成果:

在加利福尼亚州,幼儿期MMR免疫率与自闭症发生趋势之间没有明显的相关性.
自闭症病例数量从1980年到1994年显著增加 (373%的相对增长).
24个月后的MMR免疫覆盖率显示在同一时期略有增加 (14%的相对增加).

结论:

该研究的结果不支持MMR疫苗接种在幼儿中与自闭症发病率增加之间的关联.
数据表明,自闭症诊断的增加不能归因于MMR疫苗接种率.

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