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Updated: Mar 1, 2026

Phage-Mediated Genetic Manipulation of the Lyme Disease Spirochete Borrelia burgdorferi
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麻风菌中发生的大规模基因衰变.

S T Cole1, K Eiglmeier, J Parkhill

  • 1Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, Paris, France. stcole@pasteur.fr

Nature
|March 10, 2001
PubMed
概括

麻风细菌Mycobacterium leprae经历了极端的基因组缩小,失去了许多基因和代谢功能. 这解释了其缓慢的生长和无法在实验室培养的原因,为这种慢性神经疾病提供了洞察力.

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