Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Supercharging collaboration for bipolar research-Breakthrough discoveries for thriving with bipolar disorder (BD<sup>2</sup> ).

Bipolar disorders·2023
Same author

Alcohol metabolism contributes to brain histone acetylation.

Nature·2019
Same author

Overdispersion models for correlated multinomial data: Applications to blinding assessment.

Statistics in medicine·2019
Same author

VGF function in depression and antidepressant efficacy.

Molecular psychiatry·2017
Same author

The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling.

Molecular psychiatry·2017
Same author

Dataset of Arabidopsis plants that overexpress FT driven by a meristem-specific KNAT1 promoter.

Data in brief·2016

相关实验视频

Updated: May 26, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

从基因组学习关于成的知识.

E J Nestler1, D Landsman

  • 1Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas 75390-9070, USA. eric.nestler@utsouthwestern.edu

Nature
|March 10, 2001
PubMed
概括

了解毒生物学正在通过基因组测序进步. 这项研究确定了参与成风险和药物诱导变化的基因,重点关注神经受体脱敏.

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 吸毒成是一种复杂的疾病,涉及心理,社会和生物因素.
  • 重复接触毒品会改变易受伤害的个体的大脑功能,这是成的生物学基础.
  • 基因组测序提供了一个强大的工具来调查成的遗传基础.

研究的目的:

  • 探索基因组测序如何阐明药物成的生物机制.
  • 识别导致个体容易成的基因.
  • 通过发现药物诱导成行为的基因.

主要方法:

  • 利用了人类基因组序列数据的草稿.
  • 寻找与受体脱敏相关的基因.
  • 专注于在神经系统中调解药物滥用效应的受体.

主要成果:

  • 确定了与神经受体脱敏相关的候选基因.
  • 证明了基因组测序在成研究中的有用性.
  • 为理解遗传风险和药物诱导的变化提供了基础.

结论:

更多相关视频

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

相关实验视频

Last Updated: May 26, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

  • 基因组测序对于揭开药物成的复杂生物学是至关重要的.
  • 识别特定的基因可以揭示个体的脆弱性和成的神经生物学途径.
  • 这种方法有助于发现成治疗的分子标.