巨细胞通过C反应性蛋白介导的低密度脂蛋白吸收:对动脉样硬化的影响
T P Zwaka1, V Hombach, J Torzewski
1Internal Medicine II-Cardiology, University of Ulm, Ulm, Germany.
Circulation
|March 10, 2001
概括
C-反应蛋白 (CRP) 可能有助于低密度脂蛋白 (LDL) 在动脉中沉积,从而导致泡细胞的形成. 巨细胞通过巨细胞酶酶 (macropinocytosis) 吸收CRP-opsonized的LDL,从而导致动脉样硬化.
科学领域:
- 心血管生物学 心血管生物学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 低密度脂蛋白 (LDL) 和C反应蛋白 (CRP) 是主要的心血管风险因素.
- 在动脉样硬化期间,LDL和CRP都会在动脉壁中积累.
- 原生LDL不会诱导泡细胞的形成,这表明其他因素的作用.
研究的目的:
- 为了调查C反应蛋白 (CRP) 是否可以使本地LDL被巨细胞吸收.
- 为了阐明CRP介导的LDL由巨细胞吸收的机制.
主要方法:
- 人体单细胞的分离和分化为巨细胞.
- 使用免疫光标签和共聚焦激光扫描显微镜评估CRP/LDL吸收.
- 研究CRP受体CD32在CRP/LDL吸收中的作用.
主要成果:
- 巨细胞很容易吸收本地LDL,当与CRP并存时.
- 这种吸收是通过一种称为巨细胞细胞分解的过程发生的.
- 鉴定出CRP受体CD32是CRP/LDL吸收的媒介.
结论:
- CRP对本地LDL产生作用,促进其被巨细胞吸收.
- 巨细胞吸收CRP-opsonizedLDL有助于泡细胞的形成.
- 这种机制提供了一个潜在的解释泡细胞的形成在人类的动脉生成.
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