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在T细胞发育过程中对SLP-76适配器GADS的要求

J Yoder1, C Pham, Y M Iizuka

  • 1Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA.

Science (New York, N.Y.)
|March 10, 2001
PubMed
概括

适应蛋白GADS通过将SLP-76与LAT联系起来,对T细胞激活至关重要. 缺乏GADS严重损害T细胞的增殖和对CD3信号的反应,突出其关键作用.

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Naive T cells that have not yet encountered an antigen express two primary CD...