Xeroderma pigmentosumTFIH

J Liu1, S Akoulitchev, A Weber

  • 1Gene Regulation Section, Laboratory of Pathology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.

Cell
|March 10, 2001
PubMed
概括

在TFIIH子单元中发生的突变,Xeroderma pigmentosum (XP) B和XPD破坏了c-myc基因的转录调节. 这种微妙的转录缺陷,不仅仅是DNA修复问题,导致XP患者的癌症风险.

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