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Updated: May 12, 2026

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
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在caspase-9和Smac/DIABLO中保存的XIAP相互作用动机调节了caspase活动和亡

S M Srinivasula1, R Hegde, A Saleh

  • 1Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Nature
|March 10, 2001
PubMed
概括

与X相关的亡抑制蛋白 (XIAP) 与caspase-9结合,从而抑制了亡. 结合XIAP的smac蛋白破坏了这种相互作用,通过释放caspase-9活性来促进细胞灭绝. 这揭示了编程细胞死亡中的关键调节机制.

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