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相关概念视频

Layers of the Heart Wall01:15

Layers of the Heart Wall

The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
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Imbalances in Cardiac Output

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CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

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Myocarditis I: Introduction

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在心室动期间,心脏上心脏边界区域的波折增加,心脏中心肌梗塞已经愈合.

T Ohara1, K Ohara, J M Cao

  • 1Division of Cardiology, Cedars-Sinai Research Institute, the Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, CA, USA.

Circulation
|March 14, 2001
PubMed
概括

在心肌梗塞的心脏中,心上边界区域在心室动 (VF) 期间显示出增加的波折,支持动作潜力持续时间恢复假设.

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科学领域:

  • 心血管生理学心血管生理学
  • 心脏电生理学 心脏电生理学
  • 心肌梗塞研究研究

背景情况:

  • 在患有慢性心肌梗塞的心脏上表心边界区域 (EBZ) 的心室动 (VF) 期间波断的机制尚不清楚.
  • 了解这种现象对于在心脏病发作后患者中开发针对性治疗VF至关重要.

研究的目的:

  • 为了研究EBZ在VF期间波动力学中的作用,在已治愈心肌梗塞的犬类模型中.
  • 确定行动潜力持续时间 (APD) 归还假设是否解释了EBZ的波折.

主要方法:

  • 在诱导心肌梗塞和对照犬的狗中诱导VF和对EBZ和周围区域的顺序映射.
  • 高分辨率电极映射以分析波浪,再入模式和近似.
  • 在EBZ中评估动态APD归还曲线和Connexin43表达式.

主要成果:

  • 与其他映射区域相比,EBZ表现出明显更高的波浪密度和自发波浪断裂的发生率.
  • 重新进入EBZ的特点是核心周长较小,旋转速度较慢,刺激间隙减少或不存在.
  • 在EBZ中的APD恢复曲线显示了更长的透气间隔,斜率大于1,并显著减少了Connexin43染色.

结论:

  • 在心肌梗塞治愈后的心脏的EBZ中,波浪断裂的选择性增加和重新进入动态的改变发生.
  • 这些发现与行动潜力持续时间归还假设相一致,即作为在VF期间EBZ中增加波折的机制.