细胞壁缺乏的细菌和培养负的发烧发作在骨髓移植接受者
1Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
Lancet (London, England)
|March 15, 2001
概括
缺乏细胞壁的细菌是骨髓移植 (BMT) 接受者不明原因发烧的关键原因. 识别这些生物可以改善 BMT 患者培养负热发作治疗结果.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 微生物学 微生物学
背景情况:
- 中性衰竭发烧在骨髓移植 (BMT) 接受者中很常见,通常有未确定的原因.
- 虽然感染是可疑的,但微生物学确认是罕见的,使许多中性衰竭发烧病例无法解释.
- 细胞壁缺陷细菌在BMT相关发烧中的作用需要进一步调查.
研究的目的:
- 在骨髓移植接受者中调查细胞壁缺乏细菌的患病率和临床意义.
- 确定这些生物对培养负热发作事件的贡献.
- 为了将微生物学发现与患者的临床特征相关联.
主要方法:
- 来自BMT受体的血液培养物使用标准有氧,无氧和专门的细胞壁缺陷细菌培养瓶进行了分析.
- 从阳性培养物中分离出来的细胞被用标准的生化方法鉴定出来.
- 微生物学结果与患者的临床数据相关,包括中性衰竭期.
主要成果:
- 来自86名BMT受体的798种血液培养物中,20组仅在缺乏细胞壁的细菌培养瓶中产生了分离物.
- 大多数这些分离物 (85%) 是阳性,包括葡萄球菌和细菌物种.
- 抗生素治疗在与细胞壁缺乏细菌相关的20个病例中95%成功.
结论:
- 缺乏细胞壁的细菌是BMT受体中培养负热发作的重要原因.
- 检测到这些生物体可以解释以前无法解释的发烧在这个脆弱的患者群体.
- 针对细胞壁缺乏细菌的向检测方法对于准确的诊断和BMT患者的有效管理至关重要.
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