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在幼儿时期的急性呼吸道感染和曼诺结合性莱克缺乏

A Koch¹, M Melbye, P Sørensen

¹Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. ako@ssi.dk

|March 20, 2001

概括

曼诺结合性莱克 (MBL) 缺乏症显著增加了幼儿急性呼吸道感染 (ARI) 的风险. 这种增加的敏感性在6至17个月之间最明显,这是免疫发育的关键时期.

科学领域:

免疫学免疫学免疫学
儿科儿科儿科
遗传学是一个遗传学.

背景情况:

低血清曼诺结合性莱克 (MBL) 水平,通常是由于MBL变体等位基因,在医院研究中与增加感染易感性有关.
在人口层面上,MBL缺乏对常见的儿童感染的影响仍然在很大程度上是未知的.

研究的目的:

确定MBL不足与两岁以下儿童急性呼吸道感染 (ARI) 风险之间的关联.
研究遗传因素在宿主防御常见儿童感染中的作用.

主要方法:

一项基于人口的前性队列研究在格陵兰的西西穆特进行.
在两年内,每周监测252名两岁以下的儿童的发病率.
从血液样本中确定MBL基因型,并根据临床评估和病史评估ARI风险.

主要成果:

与MBL不足儿童相比,MBL不足儿童的ARI相对风险增加了2.08倍 (RR) (P<.001).与MBL不足儿童相比,ARI的相对风险增加了2.08倍.
增加的风险在6至17个月的儿童中最为显著 (RR,2.92).
在0-5个月的婴儿中观察到较小的影响 (RR,1.47),在18-23个月的婴儿中没有显著的影响 (RR,1.00).

结论:

遗传因素,特别是MBL不足,在儿童对感染的免疫防御中起着至关重要的作用.
这种脆弱性在6-17个月的年龄段尤其明显,与不成熟的适应性免疫系统相吻合.

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