绝经后妇女的生殖期和痴呆风险
M I Geerlings1, A Ruitenberg, J C Witteman
1Department of Epidemiology and Biostatistics, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, the Netherlands. geerlings@epib.fgg.eur.nl
JAMA
|March 23, 2001
概括
在自然更年期的女性中,更长的生殖期与痴呆和阿尔茨海默病 (AD) 的风险增加有关. 这一发现不支持长时间暴露于雌激素会降低痴呆风险的假设.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 生殖内分泌学 生殖内分泌学
背景情况:
- 外源性雌激素的使用与绝经后妇女的痴呆风险降低有关.
- 长期内源性雌激素暴露对痴呆风险的影响在很大程度上尚未研究.
研究的目的:
- 为了研究更长的生殖期之间的联系,作为内源性雌激素暴露的代理,以及经历过自然更年期的女性痴呆和阿尔茨海默病 (AD) 的风险.
主要方法:
- 鹿特丹研究是一项基于荷兰人口的前性队列研究.
- 包括3601名55岁以上没有基线痴呆症的女性,评估初潮和更年期的年龄.
- 对痴呆症和AD发病率进行了监测,并在生殖期长度的四分位数中进行了比较.
主要成果:
- 在21,046人年中,199名女性患有痴呆症 (159名患有痴呆症).
- 在对共变量进行调整后,自然更年期和更长的生殖期 (>39年) 的女性显示痴呆风险增加 (调整后RR,1.78) 和AD (调整后RR,1.51).
- 这种增加的风险在APOE ε4载体中最为明显.
结论:
- 研究结果不支持假设,更长的生殖期保护自然更年期的妇女免受痴呆症.
- 相反,更长的生殖期可能与痴呆和AD的风险增加有关.
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