腹腔大动脉质沉积是血管发病率和死亡率的重要预测因素
P W Wilson1, L I Kauppila, C J O'Donnell
1From the NHLBI's Framingham Heart Study and Boston University School of Medicine, Framingham, Massachusetts, USA.
Circulation
|March 21, 2001
概括
在腰部X射线上检测到的腹腔大动脉 (AAC) 沉积物预测心血管疾病 (CVD) 风险. 增加的AAC水平与较高的冠心病,心血管疾病和死亡率有关,这突显了其在风险评估中的价值.
科学领域:
- 心血管流行病学心血管流行病学
- 放射学 放射学是一门学科.
- 血管疾病研究研究.
背景情况:
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 对心血管疾病的预测标志物对于早期干预和风险分层至关重要.
- 腹部动脉沉积在长期心血管疾病预测中的作用需要进一步研究.
研究的目的:
- 为了评估腹腔大动脉 (AAC) 检测到侧腰部放射片作为预测发生冠心病 (CHD),心血管疾病和心血管疾病死亡率.
- 评估大队伍中不同程度的AAC和长期血管事件率之间的关联.
- 确定AAC是否是血管发病率和死亡率的独立预测因素.
主要方法:
- 从1967年到1989年,对1049名男性和1466名女性 (平均年龄61岁) 的队列进行了跟踪.
- 侧腰部放射图分析了前后腹部大动脉沉积物 (AAC),使用经过验证的0-24点尺度.
- 使用比例危险逻辑回归模型来评估AAC三角形与发生性心血管疾病,心血管疾病和心血管疾病死亡率之间的关联,并根据多种风险因素进行调整.
主要成果:
- 较高的AAC三位数与男性和女性心血管疾病的相对风险显著增加,与最低的三位数相比.
- 多变量分析表明,AAC是发生性心血管疾病,心血管疾病和心血管疾病死亡率的重要预测因素.
- 对于心血管疾病和心血管疾病的死亡率也观察到类似的关联,这表明在不同的血管终点上具有一致的预测值.
结论:
- 腹腔大动脉 (AAC) 沉积物,可以在侧腰部放射图上识别,作为亚临床动脉样硬化疾病的标志物.
- AAC是随后的血管发病率和死亡率的独立预测因素.
- 对AAC进行例行放射性评估可能有助于识别未来心血管事件风险较高的个体.
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