从一个不跳动心脏的捐赠者的肺部移植
1Heart-Lung Division, University Hospital of Lund, Sweden. stig.steen@thorax.lu.se
Lancet (London, England)
|March 27, 2001
概括
这项研究证明了从非心跳的捐赠者中成功移植人类肺部. 伦理考虑和活体评估为这种救命程序铺平了道路.
科学领域:
- 心血管外科心血管外科
- 移植医学 移植医学
- 生物伦理学生物伦理学
背景情况:
- 之前的动物研究证实了非心跳的捐赠者的肺移植成功.
- 为了评估捐赠者的肺功能,开发了一个ex-vivo器官评估系统.
- 该研究旨在在伦理上适应和实施人类的非心跳供体肺移植.
研究的目的:
- 确定从NHBD中进行人类肺移植的伦理上可接受的程序.
- 引导从NHBD进行的第一个临床肺移植.
主要方法:
- 在瑞典,通过公众信息计划和专业讨论评估了伦理的可接受性.
- 捐赠者的肺部在死后65分钟就在现场冷却.
- 肺部在取回后和移植前被评估为活体.
主要成果:
- 没有发现移植的禁忌.
- 一名患有COPD的54岁妇女成功接受了右肺移植手术.
- 移植的肺在输血后和5个月的随访期间表现出很好的功能.
结论:
- 心脏病和脑血管疾病死亡人数代表着一个重要的潜在捐赠者池.
- 在NHBD协议中培训医疗保健专业人员可以增加捐赠肺的可用性.
- 这种方法提供了一个可行的解决方案,解决了供体肺部移植的质量供体肺部短缺问题.
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