芬兰尿液中的分泌和心血管死亡率:一项前性研究
J Tuomilehto1, P Jousilahti, D Rastenyte
1Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland. Jaakko.Tuomilehto@ktl.fi
Lancet (London, England)
|March 27, 2001
概括
高盐摄入量,通过24小时尿液分泌量来衡量,独立地增加心血管疾病和死亡的风险. 这项研究提供了直接证据,表明高消费对成年人的有害影响.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 营养科学 营养科学
背景情况:
- 高盐摄入量与心血管疾病 (CVD) 风险之间的联系受到争论.
- 调查盐摄入量作为独立心血管疾病风险因素的作用至关重要.
研究的目的:
- 为了确定盐的摄入,通过24小时尿液分泌评估,独立预测心血管疾病的频率和死亡率.
- 评估分泌与全因死亡率之间的关联.
主要方法:
- 对2396名芬兰成年人 (25-64岁) 的预期随访.
- 测量24小时尿液内分泌量和心血管风险因素.
- 使用Cox比例危险模型分析发生的冠状动脉和中风事件,以及死亡率.
主要成果:
- 尿液24小时内分泌量增加100mmol与冠状动脉心脏病 (1.51),心血管疾病 (1.45) 和全因死亡率 (1.26) 的危险比率增加相关.
- 增加的分泌与较高的急性冠状动脉事件有关,但与中风事件无关.
- 摄入量预测了超重男性的死亡率,这表明与体重指数的相互作用.
结论:
- 高摄入量是死亡率和冠心病风险的独立预测因素,甚至超出了血压.
- 这些发现直接证明了高盐消费对成年人群健康的不利影响.
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