孕产妇内皮功能障碍与妊娠前的关联
J C Chambers1, L Fusi, I S Malik
1National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, England. j.kooner@ic.ac.uk
JAMA
|April 13, 2001
概括
患有妊娠前史的妇女在分娩后表现出内皮功能受损,这与氧化应激有关. 用甲酸治疗抗氧化剂改善了血管功能,这表明这些女性的治疗点.
科学领域:
- 产科和妇科 产科和妇科
- 心血管研究研究心血管研究
- 血管生物学 血管生物学
背景情况:
- 孕前与胎盘因素有关,这些因素会损害母亲的血管内皮.
- 以前的研究,仅限于怀孕,无法隔离内皮功能障碍的母体与胎盘机制.
研究的目的:
- 为了研究先前患有先兆子的非孕妇的内皮功能.
- 要确定氧化应激是否在这些女性中介于内皮功能障碍.
主要方法:
- 一项病例对照研究比较了113名先前患有妊娠前的妇女和48名对照者的内皮功能 (流媒体和三酸甘诱导的扩张).
- 在静脉注射 Askorbic 酸后重复测量以评估氧化应激.
主要成果:
- 与对照组相比,先前患有妊娠前的女性表现出明显较低的流体介导扩张.
- 内皮独立扩张在不同组中是相似的.
- 亚斯科布酸在先前预先产卵的妇女中改善了流媒体扩张,但不是对照组,表明氧化应激参与.
结论:
- 内皮功能障碍在有先兆子史的妇女中持续产后.
- 这种功能障碍并不能用传统的血管风险因素来解释.
- 抗氧化剂治疗与 Askorbic 酸显示出逆转内皮损伤的潜力.
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