早产婴儿的早期营养和晚期血压:随机试验后的两个队列
1Medical Research Council Childhood Nutrition Research Centre, Institute of Child Health, London, UK. a.singhal@ich.ucl.ac.uk
Lancet (London, England)
|March 29, 2001
概括
婴儿时期的母乳养与晚年早产儿的血压降低有关. 这项研究提供了证据,早期营养计划心血管风险因素,突出母乳乳.
科学领域:
- 儿童营养学 儿童营养学
- 心血管健康 心血管健康
- 健康和疾病的发育起源 (DOHaD)
背景情况:
- 人们假设早期的营养会影响以后的心血管结果.
- 以前关于母乳养和血压的研究缺乏随机对照试验.
- 这项研究旨在实验研究早期饮食对血压的编程效应.
研究的目的:
- 为了测试早期饮食在晚年规划血压的假设.
- 评估不同新生儿养策略对血压的长期影响.
- 为营养在心血管风险规划中的作用提供实验证据.
主要方法:
- 一项随机对照试验,涉及英国新生儿单位的早产婴儿.
- 捐赠母乳与早产婴儿奶粉的比较.
- 测量血压在13-16岁的年龄在队列的一个子集.
主要成果:
- 与早产婴儿配方奶粉相比,在13-16岁时,分配给储存母乳的儿童的平均动脉血压较低.
- 观察到新生儿人乳摄入量与后来的血压之间存在显著的反向关系.
- 在产后配方组和产前配方组之间没有发现血压的显著差异.
结论:
- 新生儿母乳消费与早产儿血压降低有关.
- 早期的饮食在编程心血管风险因素方面起着重要作用.
- 这些发现支持母乳对心血管健康的长期益处.
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