骨髓细胞再生心肌梗塞的心肌梗塞
D Orlic1, J Kajstura, S Chimenti
1Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA.
Nature
|April 5, 2001
概括
在心肌梗塞后将骨髓细胞移植到小鼠身上,可再生出新的心肌组织. 这项研究表明,骨髓干细胞有可能修复心脏损伤并改善心脏功能.
科学领域:
- 再生医学是一种再生医学.
- 心血管生物学 心血管生物学
- 干细胞生物学 干细胞生物学
背景情况:
- 心肌梗塞导致不可逆转的心脏组织损失和功能衰退.
- 心脏缺乏内在的再生能力,导致心脏病发作后的病情逐渐恶化.
- 遥远的干细胞可以迁移到受伤部位,并通过分化促进组织修复.
研究的目的:
- 为了研究骨髓细胞在心肌梗塞的小鼠模型中恢复死心肌的潜力.
- 评估局部输送的骨髓细胞是否可以产生新的心脏组织并改善心脏功能.
主要方法:
- 从表达增强绿色光蛋白的转基因小鼠中分离出骨髓细胞.
- 阴性 (Lin-) c-kit-阳性 (POS) 细胞使用光激活细胞分类进行了分类.
- 在冠状动脉绑定后不久,这些细胞被注射到小鼠的心脏病发作的边界区域.
主要成果:
- 移植后9天,新形成的心肌占据了心脏梗塞腹腔区域的68%.
- 再生的组织由增殖的肌细胞和新形成的血管结构组成.
- 移植的骨髓细胞成功地产生了新的心肌和血管系统.
结论:
- 当地输送的骨髓细胞可以分化为功能性心肌.
- 骨髓细胞移植是心肌梗塞后心脏组织修复的有希望的策略.
- 这种方法有可能改善冠状动脉疾病的结果.
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