基乙醇粉和凝对严重败血症功能的影响:一项多中心随机性研究
F Schortgen1, J C Lacherade, F Bruneel
1Medical Intensive-care Unit, Henri Mondor Hospital, Assistance Publique-H pitaux de Paris, University Paris 12, Créteil, France.
Lancet (London, England)
|April 6, 2001
概括
在严重败血症患者中,基乙粉的使用显著增加了急性功能衰竭 (ARF) 风险,而不是等. 这项研究强调基乙粉是重症患者ARF的独立风险因素.
科学领域:
- 临界护理医学 临界护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 基乙 (HES) 用于液体复苏.
- 之前的研究表明,HES可能会损害移植受体的功能.
- 在严重败血症患者中,HES的安全性需要进一步调查.
研究的目的:
- 评估严重败血症或败血性休克患者急性功能衰竭 (ARF) 的频率.
- 为了比较用基乙粉 (HES) 和凝治疗的患者之间的ARF发病率.
主要方法:
- 一个多中心的随机研究,涉及严重败血症或败血性休克的成年人.
- 患者被分配给接受6%的基乙烯粉或3%的液体修饰凝.
- 主要终点是ARF,定义为血清肌素增加两倍或需要替代疗法.
主要成果:
- 招募了129名患者;基线特征在各组之间相似.
- 在HES组中,ARF发生在42%的患者中,而在凝组中为23% (p=0.028).
- 使用HES被确定为ARF的独立风险因素 (OR2.57,p=0.026).
结论:
- 这种基乙醇粉制剂是严重败血症或败血性休克患者ARF的独立风险因素.
- 在这种患者群体中,凝可能是液体复苏的更安全替代品.
- 需要进一步的研究来阐明HES诱导的毒性背后的机制.
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