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相关概念视频

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

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Updated: Jul 14, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

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Published on: January 16, 2019

基乙醇粉和凝对严重败血症功能的影响:一项多中心随机性研究.

F Schortgen1, J C Lacherade, F Bruneel

  • 1Medical Intensive-care Unit, Henri Mondor Hospital, Assistance Publique-H pitaux de Paris, University Paris 12, Créteil, France.

Lancet (London, England)
|April 6, 2001
PubMed
概括

在严重败血症患者中,基乙粉的使用显著增加了急性功能衰竭 (ARF) 风险,而不是等. 这项研究强调基乙粉是重症患者ARF的独立风险因素.

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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

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10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

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科学领域:

  • 临界护理医学 临界护理医学
  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 基乙 (HES) 用于液体复苏.
  • 之前的研究表明,HES可能会损害移植受体的功能.
  • 在严重败血症患者中,HES的安全性需要进一步调查.

研究的目的:

  • 评估严重败血症或败血性休克患者急性功能衰竭 (ARF) 的频率.
  • 为了比较用基乙粉 (HES) 和凝治疗的患者之间的ARF发病率.

主要方法:

  • 一个多中心的随机研究,涉及严重败血症或败血性休克的成年人.
  • 患者被分配给接受6%的基乙烯粉或3%的液体修饰凝.
  • 主要终点是ARF,定义为血清肌素增加两倍或需要替代疗法.

主要成果:

  • 招募了129名患者;基线特征在各组之间相似.
  • 在HES组中,ARF发生在42%的患者中,而在凝组中为23% (p=0.028).
  • 使用HES被确定为ARF的独立风险因素 (OR2.57,p=0.026).

结论:

  • 这种基乙醇粉制剂是严重败血症或败血性休克患者ARF的独立风险因素.
  • 在这种患者群体中,凝可能是液体复苏的更安全替代品.
  • 需要进一步的研究来阐明HES诱导的毒性背后的机制.