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相关概念视频

The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...

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相关实验视频

Updated: May 8, 2026

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

在缺乏纤维细胞生长因子9的小鼠中,男性到女性的性别逆转.

J S Colvin1, R P Green, J Schmahl

  • 1Department of Molecular Biology and, Pharmacology, Washington University Medical School, Campus Box 8103, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

Cell
|April 6, 2001
PubMed
概括

纤维细胞生长因子9 (FGF9) 对于小鼠的男性性别确定至关重要. 它的缺失导致男性对女性的性别逆转,突出FGF信号传递.

科学领域:

  • 发育生物学是发展生物学.
  • 遗传学 是一个遗传学.
  • 生殖生物学 生殖生物学

背景情况:

  • 已知纤维细胞生长因子9 (FGF9) 能指导肺,四肢和前垂体等器官的胚胎发生.
  • 在丸发育和性别决定中,FGF信号的作用尚未完全被理解.

研究的目的:

  • 调查纤维细胞生长因子9 (FGF9) 在丸胚胎生成和男性性别决定中的作用.
  • 阐明FGF9信号在发育中的胚胎丸中的下游影响.

主要方法:

  • 对Fgf9淘汰 (Fgf9(-/-)) 鼠标模型的分析.
  • 在Fgf9的生殖系统的表型特征{-/-) 小鼠.
  • 检查胚胎丸中的基因表达和细胞分化途径.

主要成果:

  • Fgf9(-/-) 小鼠呈现男性-女性性别逆转,XY生殖系统在出生时显得粗暴的女性.
  • 这些小鼠还表现出肺部低成形和围产死亡率.
  • Fgf9似乎调节介质细胞增殖,介质细胞迁移和塞尔托利细胞分化,作用于Sry.下游.

结论:

  • 纤维细胞生长因子9 (FGF9) 在丸胚胎生成和男性性别决定中发挥着关键和新的作用.

更多相关视频

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors
11:46

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

Published on: December 14, 2018

相关实验视频

Last Updated: May 8, 2026

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors
11:46

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

Published on: December 14, 2018

  • 鉴于其保护,FGF信号可能是各种物种繁殖系统发展的保存机制.