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益生菌用于原发性疾病的预防:一个随机的安慰剂对照试验
M Kalliomäki1, S Salminen, H Arvilommi
1Department of Paediatrics, University of Turku and Turku University Hospital, Finland. markal@utu.fi
Lancet (London, England)
|April 12, 2001
概括
补充Lactobacillus GG显著减少了高风险婴儿的早期亚托皮性疾病. 这种益生菌可能通过调节肠道微生物群来提供一种新的预防过敏的策略.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 西方社会中阿托皮性疾病的增长率与早期微生物暴露的减少有关 (卫生假说).
- 益生菌,有益的肠道细菌,正在研究作为一种抵消这一趋势的方法.
- 乳酸菌GG是一种安全且经过研究的益生菌,具有潜在的抗过敏特性.
研究的目的:
- 评估Lactobacillus GG在预防高风险婴儿早期发病的亚托皮性疾病方面的疗效.
- 评估产前和产后Lactobacillus GG补充剂对阿托皮性疾病发展的影响.
主要方法:
- 进行了一项双盲,随机,安慰剂对照试验.
- 患有亚托皮性疾病高风险的母亲在产前接受了Lactobacillus GG.
- 婴儿在产后6个月内接受了Lactobacillus GG,主要终点是亚托皮性湿疹.
主要成果:
- 到2岁时,在Lactobacillus GG组的23%的婴儿中诊断出亚托皮性湿疹,而在安慰剂组的婴儿中,这一比例为46%.
- 在益生菌组中,发展亚托皮性湿疹的相对风险为0.51.
- 需要用Lactobacillus GG治疗的患者数量,以预防一种亚托皮性湿疹病例是4.5.
结论:
- 补充Lactobacillus GG在预防高风险儿童早期的亚托皮性疾病方面表现出有效性.
- 通过益生菌调节肠道微生物群,为预防亚托皮性疾病提供了潜在的途径.
- 这项研究强调益生菌作为天然免疫调节剂,用于管理过敏症.
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