莱普调节的内分泌大麻素参与维持食物摄入
V Di Marzo1, S K Goparaju, L Wang
1Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072, Arco Felice, Naples, Italy.
Nature
|April 12, 2001
概括
位于下丘脑中的内分类素激活CB1受体,影响食物摄入. 莱普信号传递缺陷会增加内分泌大麻素,这表明它在肥胖和能量平衡中起作用.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
背景情况:
- 瘦素是一种关键激素,通过下丘脑信号调节食欲和能量平衡.
- 肥胖可能是由于莱普或黑色素cortin通路中的遗传缺陷造成的.
- 存在其他刺激食欲的途径,例如涉及CB1受体的途径.
研究的目的:
- 研究CB1大麻素受体和内分泌大麻素在下丘脑中的作用.
- 为了确定勒普丁信号传递和内分泌大麻素水平之间的关系.
- 探索连接瘦素和食欲调节的神经回路.
主要方法:
- 使用CB1受体淘汰小鼠和野生类型的 littermates.
- 使用的CB1抗剂SR141716A.
- 在各种肥胖小鼠模型 (db/db, ob/ob) 和大鼠中测量了下丘脑内内可纳素水平.
- 评估了急性瘦素治疗对内分泌卡纳比诺伊德水平的影响.
主要成果:
- 与对照组相比,CB1受体淘汰小鼠在食物限制后食物摄入量减少.
- SR141716A 野生型小鼠的食物摄入量下降,但绝杀小鼠的食物摄入量没有下降.
- 瘦素缺乏的肥胖模型显示了高水平的下丘脑内分泌大麻素.
- 在正常和肥胖的小鼠中,勒普治疗降低了下丘脑内分泌大麻素水平.
结论:
- 作用于CB1受体的下丘脑内分泌大麻素可能有力地刺激食物摄入.
- 内体大麻素信号传递与勒调节的神经通路有关.
- 这一途径代表了管理食欲和能量平衡的潜在目标.
相关概念视频
Neural Regulation
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Hormonal Regulation
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Regulation of the Digestive System
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of these...
The effectors in this regulation system are glands and smooth muscles. Activation of these...
Intestinal Phase of Digestion
The intestinal phase of digestion is the third and final stage of the digestive process, occurring after the cephalic and gastric phases. It begins when chyme, a partially digested mixture of food and digestive enzymes, enters the small intestine from the stomach. This phase is crucial for nutrient absorption and involves complex hormonal and enzymatic interactions.
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
Regulation of Food Intake
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...


