心率变化的关系与副交感效应的关系
J J Goldberger1, S Challapalli, R Tung
1Division of Cardiology, Department of Medicine, Northwestern University, Chicago, Illinois, USA. goldberger@nwu.edu
Circulation
|April 18, 2001
概括
心率变化 (HRV) 和副交感神经系统影响之间的关系最好用二次函数来描述,而不是线性函数. 这表明HRV随着副交感效应增加到一个点,然后下降.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能 自主神经系统功能
背景情况:
- 巴罗反射激活通过副交感刺激影响心率变化 (HRV).
- 副交感效应和HRV之间的确切关系尚未完全理解,观察到的反应是可变的.
研究的目的:
- 调查二次函数是否比线性函数更好地描述HRV和副交感效应之间的关系.
- 分析年龄对HRV对副交感调制反应的影响.
主要方法:
- 29名健康的志愿者接受了β-上腺素阻塞.
- 脑电图记录是在烯和酸注射期间获得的,以调节巴罗反射活动.
- 时间和频域HRV测量用线性和二次函数计算和建模.
主要成果:
- 与线性模型相比,一个二次模型,与二次项的负系数,为数据提供了更好的匹配.
- 年龄对特定HRV参数 (MSSD和pNN50) 对偏交效应变化的响应有显著影响.
结论:
- HRV和副交感效应之间的关系是非线性的,其特点是HRV的初始增加,平原,然后随着副交感活动的增加而下降.
- 人际HRV的个体间变化可能源于这种非线性关系的差异或自主神经系统影响的变化.
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