之前的酒精消耗和急性心肌梗塞后的死亡率
K J Mukamal1, M Maclure, J E Muller
1Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, LY-303, Boston, MA 02215, USA. kmukamal@caregroup.harvard.edu
JAMA
|April 20, 2001
概括
在急性心肌梗塞 (AMI) 之前适度饮酒与较低的长期死亡率有关. 这项研究发现,与不饮酒者相比,每周饮酒量高达7杯或更多的人在AMI后的死亡率有所降低.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,适度饮酒可能会降低第一次急性心肌梗塞 (AMI) 的风险.
- 在AMI前饮酒对幸存者死亡率的影响尚不清楚.
研究的目的:
- 研究先前的酒精消费与 AMI 幸存患者的长期死亡率之间的关联.
- 基于自报的每周酒精摄入量 (酒,葡萄酒,烈酒) 在AMI前一年分析死亡率.
主要方法:
- 潜在的开始队列研究涉及1913名成年AMI幸存者在45家美国医院 (1989-1994).
- 平均随访时间为3.8年.
- 评估与自我报告的酒精消费水平相关的所有原因死亡率 (禁酒者,<7杯/周,≥7杯/周).
主要成果:
- 饮酒量低于7杯/周的患者的死亡率比不饮酒者低45% (HR 0.55).
- 那些每周饮用7杯以上饮料的人的死亡率比不饮酒的人低62% (HR 0.38).
- 经过对混因素的调整后,适度饮酒 (<7杯/周和≥7杯/周) 仍然与显著降低的死亡率相关 (调整后的HR分别为0.79和0.68).
结论:
- 在AMI之前的一年内,自我报告的中度饮酒与减少长期死亡率有关.
- 这些发现表明,适度饮酒对心肌梗塞后的存活率有潜在的保护作用.
- 这种关联在不同饮料类型,性别以及总和心血管死亡率上都是一致的.
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