在随机对照试验中,医生对盲目术语的解释和教科书定义
P J Devereaux1, B J Manns, W A Ghali
1Department of Medicine, McMaster University, 1200 Main St W, Room 2C12, Hamilton, Ontario, Canada L8N 3Z5. philipj@mcmaster.ca
JAMA
|April 20, 2001
概括
在随机对照试验 (RCT) 中,医生对单,双和三盲的解释和教科书定义显示出显著的差异. 建议对失明状态做出更明确的声明,以提高研究的清晰度.
科学领域:
- 临床研究方法论 临床研究方法论
- 基于证据的医学基于证据的医学.
背景情况:
- 临床医生通常通过评估失明状态来评估随机对照试验 (RCT).
- 目前用于盲目的术语 (单,双,三) 受到各种解释.
研究的目的:
- 为了确定医生如何解释RCT中的盲目术语.
- 分析单一,双重和三重失明的教科书定义.
主要方法:
- 在加拿大三个大学的第三级护理中心进行了一项观察性研究.
- 91名内科医生完成了一项关于他们对失明的理解的调查.
- 视障的定义是从1990年以来出版的25本教科书中提取的.
主要成果:
- 医生分别为单眼,双眼和三眼失明提供了10,17和15种不同的解释.
- 教科书为每个失明级别提供了5,9和7个不同的定义.
- 在医生解释和教科书定义中都观察到很高的变化,特别是在双重和三重失明方面.
结论:
- 医生之间以及医学教科书中对盲目术语的解释和定义存在重大差异.
- 像"单一"",双重"和"三重"盲目的模糊术语应该被明确声明所取代,详细说明RCT中所有参与方的盲目的状态.
相关概念视频
Blind Procedures
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Randomized Experiments
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Simple randomization
Simple...
Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
Blinding
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Confounding in Epidemiological Studies
Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This phenomenon...


