相关实验视频
Updated: Jul 15, 2026

13:42
A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
Published on: July 17, 2012
概括
随着时间的推移,冠状动脉封闭后,心上ST段的升高 (ST) 分布会发生变化. 早期缺血症显示均的ST,而晚期缺血症显示的梯度,影响了当前的伤害模型.
科学领域:
- 心血管生理学心血管生理学
- 缺血性心脏病研究 缺血性心脏病研究
- 生物医学工程 生物医学工程
背景情况:
- 冠状动脉封闭导致心肌缺血,改变心脏的电活动.
- 心ST段升高 (ST) 是急性心肌梗塞的一个关键指标.
- 了解ST动态对于诊断和管理缺血事件至关重要.
研究的目的:
- 为了研究冠状动脉封闭后表心ST段升高 (ST) 的时空特征.
- 分析缺血区域大小的变化如何影响ST幅度和分布.
- 为了评估现有的损伤模型,目前在心肌缺血中产生损伤.
主要方法:
- 在和猪身上使用高分辨率电极阵列记录了心表电图.
- 诱导冠状动脉封闭,然后连续监测ST8小时.
- 操纵猪的缺血区域大小,观察相应的ST变化.
主要成果:
- 最初,ST在缺血区域 (前20分钟) 均.
- 经过20分钟的缺血,ST从外围向中心的梯度发生.
- 增加缺血面积显著增加了ST幅度 (58%);减少面积减少了ST (24%).
结论:
- 早期缺血 (<20分钟) 与来自缺血边界的损伤电流一致.
- 晚期缺血 (超过20分钟) 表明在整个缺血区域产生损伤电流.
- ST段的升高动态为心肌损伤的演变提供了洞察力,并为当前的损伤模型提供了信息.
相关概念视频
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Location and Orientation of the Heart
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
Heart Valves
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
Electrocardiogram Fundamentals
Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin to...
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin to...

