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一个常见的甲基四基酸减少酶突变和血类固醇与冠状动脉支架后亲密增生之间的关系.

T Kosokabe1, K Okumura, T Sone

  • 1Internal Medicine II, Nagoya University School of Medicine, Japan.

Circulation
|April 25, 2001
PubMed
概括

甲基酸酸减少酶 (MTHFR) 基因突变与冠状动脉狭窄和内脏增生症的增加有关. 这种MTHFR基因型可能会增加支架插入后支架内静止症的风险.

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科学领域:

  • 心血管医学 心血管医学
  • 遗传学 是一个遗传学.
  • 干预心脏病学 干预心脏病学

背景情况:

  • 超高囊血是冠状动脉疾病的独立危险因素.
  • 一种常见的甲基网酸缩酶 (MTHFR) 基因突变 (677 C-->T) 可能导致轻度的高血糖血症和冠状动脉疾病发病率.
  • 没有先前的研究通过血管内超声波将MTHFR基因突变或同氨酸水平与冠状动脉样硬化形态联系起来.

研究的目的:

  • 为了研究MTHFR基因多态性,血类固醇水平和冠状动脉形态之间的关联.
  • 评估MTHFR基因型对冠状动脉支架后亲密增生和复原的影响.

主要方法:

  • 查了62名患有65个冠状动脉病变的患者,这些患者接受了Palmaz-Schatz支架治疗.
  • 分析了MTHFR基因多态性 (TT与非TT基因型) 和血同氨酸水平.
  • 利用血管和血管内超声波分析来评估百分比直径狭窄和内脏增生区域.

主要成果:

  • 与非TT基因型相比,具有TT基因型的患者的直径狭窄率 (43.7%与29.0%) 和内脏增生面积 (5.70mm2与3.72mm2) 显著增加,与非TT基因型相比.
  • 血homocysteine水平在TT和非TT基因型之间没有显著差异.
  • 在MTHFR基因中T等位基因的数量是干预后亲密增生症的唯一独立预测因子.

结论:

  • 同胞性突变MTHFR基因型 (TT) 与更严重的冠状动脉样硬化和内脏增生有关.
  • 这种MTHFR基因型可能会增加冠状动脉支架后支架内静止症的风险.