高海拔肺最初是由毛细血管压力增加引起的
M Maggiorini1, C Mélot, S Pierre
1Department of Internal Medicine, UniversitätsSpital, Zürich, Switzerland. klinmax@usz.unizh.ch
Circulation
|April 25, 2001
概括
高海拔肺 (HAPE) 主要是由增加的肺毛细血管压力引起的,而不是毛细血管透性的增加. 这一发现有助于理解HAPE在高海拔地区的发展.
科学领域:
- 身体生理学 身体生理学
- 高度医学 高度医学
- 心血管研究研究心血管研究
背景情况:
- 高海拔肺 (HAPE) 涉及严重的肺高血压和炎症.
- HAPE的初始触发因素 - - 增加的压力或透性 - - 尚不清楚.
研究的目的:
- 调查肺毛细管压力和透性在HAPE发展中的作用.
- 为了比较HAPE敏感个体的血液动力学反应与不同高度的对照.
主要方法:
- 测量肺血液动力学,包括毛细血管压力 (闭塞方法).
- 通过使用67Ga标记的转激素逃逸来评估毛细管的透性.
- 对比了16名易受HAPE影响的受试者与14名在低 (490米) 和高空 (4559米) 的对照者.
主要成果:
- 敏感于HAPE的受试者表现出增加的肺血管对缺氧的活性.
- 在高海拔地区,敏感的受试者有较高的肺动脉 (37 mmHg对 26 mmHg) 和毛细血管压力 (19 mmHg对 13 mmHg).
- HAPE的发展与肺毛细血管压力>19 mmHg相关;透性没有显著差异.
结论:
- 高海拔肺最初是由肺毛细血管压力升高引起的.
- 肺毛细血管压力是HAPE病变发生的一个关键因素.
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