在健康受试者和动脉样硬化患者中,对跑步机运动的外周动脉反应
A Rozanski1, E Qureshi, M Bauman
1Department of Medicine, St Luke's/Roosevelt Hospital, New York, NY 10025, USA. AR77@columbia.edu
Circulation
|April 25, 2001
概括
冠状动脉疾病患者在运动期间表现出矛盾的血管收缩指的血液流动,与健康个体不同. 这表明与动脉样硬化相关的血管问题普遍存在.
科学领域:
- 心血管生理学心血管生理学
- 血管生物学 血管生物学
- 运动生理学 运动生理学
背景情况:
- 外周皮肤血管床,就像指尖一样,通过动脉静脉解和上腺神经来调节热量.
- 由于技术上的挑战,手指对运动的血流反应还没有得到充分的研究.
- 动脉静脉解对于温度调节至关重要,并且密集地内化.
研究的目的:
- 为了比较健康志愿者和冠状动脉疾病 (CAD) 患者在运动期间的手指脉冲波幅 (PWA) 响应.
- 通过运动诱导的血流变化来调查CAD患者的潜在血管病理.
- 评估运动血液动力学和动脉样硬化之间的关系.
主要方法:
- 采用修改的体积整流图技术来测量手指脉冲波幅度 (PWA).
- 与基线相比,运动每分钟的量化PWA变化.
- 将运动PWA反应与临床,血液动力学,心电图和心肌SPECT参数进行比较.
主要成果:
- 正常的受试者在运动期间主要表现出血管扩张;少数人有初始血管扩张,随后在高心率时血管收缩.
- 35%的CAD患者在运动开始时呈现出渐进的血管收缩,18%的患者在低心率时表现出血管收缩.
- 运动期间血管扩张的患者使用了更多的ACE抑制剂,并且比血管收缩患者获得了更高的代谢等价物.
结论:
- 大约一半的CAD患者表现出降低PWA,这表明在早期运动期间出现了外周动脉血管收缩.
- 在健康人群中没有观察到运动期间矛盾的血管收缩.
- 这些发现表明,在CAD患者中,动脉样硬化是继发于动脉样硬化的通用血管病理.
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