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在正常受试者中,乙醇诱导的心肌抑郁的差异的基础

G C Timmis, R C Ramos, S Gordon

|June 1, 1975

概括

慢性乙醇 (ETOH) 消费会损害心脏功能,在饮酒量较大的饮酒者中观察到更大的损害. 对于那些因ETOH暴露而存在心肌变化的人来说,急性ETOH影响较小.

科学领域:

心脏病学心脏病学
心血管生理学心血管生理学
毒理学毒理学毒理学

背景情况:

乙醇 (ETOH) 的消费是广泛的,具有潜在的心血管影响.
以前的研究表明,急性ETOH可能在正常个体中具有极小甚至有益的血液动力学影响.
慢性ETOH滥用是心肌病的已知原因之一.

研究的目的:

为了研究乙醇对心脏功能的急性影响,在不同程度的慢性ETOH消费的正常受试者中.
评估慢性ETOH摄入量与心脏表现之间的关系.
为了探索潜在的机制,背后的ETOH诱导心脏功能障碍.

主要方法:

利用缩时间间隔来评估32名正常人心脏功能.
根据每日平均ETOH消费 (1司以下,1司1-2司,2司以上) 将受试者分为三组.
分析了PEP,PEP指数 (PEPI),异体积缩短时间 (ICT) 和PEP/LVET比率在急性ETOH给药前后的变化.

主要成果:

患有较高慢性ETOH消费的受试者对PEP,PEPI,ICT和PEP/LVET的基线值呈现逐渐较高.
随着ETOH消耗的增加,急性ETOH的使用导致这些心脏变量的变化逐渐减少.
第一组 (低ETOH) 显示出显著的变化,而第三组 (高ETOH) 显示出非显著的变化,表明慢性心肌功能障碍.

结论:

长期暴露于乙醇导致心肌功能障碍,与消费水平成正比.
观察到的左心室喷射时间 (LVET) 和ETOH后心率增加的相对稳定性与尽管急性心肌抑郁,但心率依赖心率输出增加是一致的.
这些发现表明,慢性ETOH消费在酒精性心肌病的发展中起着作用.

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