充血性心力衰竭中的呼吸肌功能障碍:临床相关性和预后意义
F J Meyer1, M M Borst, C Zugck
1Department of Cardiology, Angiology, and Respiratory Medicine, Medical Center of the University Heidelberg, Heidelberg, Germany.
Circulation
|May 23, 2001
概括
减少的灵感肌肉强度,以最大灵感压力 (Pi(max) 衡量,是充血性心力衰竭 (CHF) 患者死亡率的重要预测因素. 这种简单的测试可以改善风险评估和心脏移植患者的选择.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
背景情况:
- 在充血性心力衰竭 (CHF) 中呼吸道肌肉强度的预后意义尚未得到充分确立.
- 呼吸道肌肉功能受损在CHF患者中很常见.
研究的目的:
- 在患有心血管衰竭的患者中调查最大吸气压 (Pi(max)) 的预后值.
- 确定Pi(max) 是否可以作为死亡率的独立预测指标.
主要方法:
- 对244名心血管衰竭患者进行前性研究.
- 测量最大的吸入压力 (Pi(max)).
- 对死亡率的随访,使用单变量和多变量Cox比例危险模型进行分析.
主要成果:
- 与对照组相比,CHF患者表现出较低的Pi(max).
- 降低Pi ((max) 与增加的死亡率有显著关联.
- max) 是预后的独立预测指标,与峰值氧气消耗 (峰值VO2) 相比,并且与LVEF结合时得到改善.
结论:
- 在CHF患者中,鼓舞性肌肉强度降低,是预后的一个新的,独立的预测因素.
- 测试是简单的,可以提高心血管疾病患者的风险分层.
- Pi ((max) 可能有助于选择心脏移植的患者.
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