介质素-6 (IL-6) 和腹腔大动脉动脉瘤的预后
K G Jones1, D J Brull, L C Brown
1Department of Vascular Surgery, Imperial College at Charing Cross Hospital, Rayne Institute, London, UK.
Circulation
|May 23, 2001
概括
腹腔大动脉动脉瘤是互白素-6 (IL-6) 的来源. IL-6促进体基因型影响IL-6水平,并预测小动脉瘤患者的存活率.
科学领域:
- 心血管生物学 心血管生物学
- 炎症研究 炎症研究
- 遗传学和基因组学 在
背景情况:
- 腹腔大动脉瘤 (AAA) 是一种复杂的疾病,炎症起着关键作用.
- 动脉瘤组织释放大量的IL-6,在AAA患者中观察到IL-6水平升高.
研究的目的:
- 确定动脉瘤壁是否是循环IL-6的重要来源.
- 调查高IL-6度是否预测动脉瘤的快速生长.
- 评估IL-6 -174 G-->C促进物多态性是否影响AAA患者的生存.
主要方法:
- 测量了19名患有大或炎症性动脉瘤的患者的腹和臂动脉中的IL-6度.
- 在466名患有小动脉瘤的患者中分析了IL-6促进体基因型 (-174 G-->C) 和血IL-6水平.
- 与动脉瘤生长和患者存活率 (心血管和全因死亡率) 相关联的IL-6水平和基因型.
主要成果:
- 在患有大/炎症性动脉瘤的患者中,IL-6度在脉动脉高于脉动脉,随着动脉瘤直径的增加而增加.
- 血IL-6或IL-6基因型与动脉瘤生长之间没有发现关联.
- 与GC和CC基因型相比,GG基因型患者的IL-6血度较低,心血管和全因死亡率降低.
结论:
- 动脉瘤壁是循环IL-6水平的重要贡献者,这些水平受遗传因素的影响.
- -174 G-->C IL-6基因型可以预测患有小腹动脉动脉瘤的患者未来的心血管死亡率.
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