哺乳动物大脑中的可扩展架构
D A Clark1, P P Mitra, S S Wang
1Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Nature
|May 11, 2001
概括
哺乳动物的大脑表现出可扩展的结构,尽管绝对大小存在很大差异,但保持一致的组成 (大脑型). 这种大脑组成,而不是体重,有效地区分了物种,并揭示了灵长类大脑发育的进化趋势.
科学领域:
- 神经科学是一个神经科学.
- 进化生物学 进化生物学
- 比较解剖学的比较解剖学
背景情况:
- 传统的对哺乳动物大脑部分的比较侧重于绝对大小,这可能是误导性的.
- 使用体重作为参考变量掩盖了真正的大脑大小关系和家族遗传意义.
研究的目的:
- 介绍一种新的测量方法,即大脑型,使用大脑本身作为尺寸参考.
- 为了研究哺乳动物分类中的大脑组成,并测试进化假设.
主要方法:
- 将大脑型定义为对大脑组成的特定物种的测量.
- 在各种哺乳动物分类中分析了大脑体积.
- 研究了灵长类动物的脑型变化和新皮层体积分数.
主要成果:
- 小脑在哺乳动物中始终占据总大脑体积的固定部分 (0.13 +/- 0.02),挑战其仅为新皮质服务的角色.
- 脑型有效地区分哺乳动物种类,使进化关系的定量测试成为可能.
- 灵长类的大脑类型显示出渐进的转变,新皮层体积分数从到人猿的增加,这表明有针对性的进化压力.
- 绝对的大脑大小在种群内有很大差异,但大脑型仍然相对均,表明大脑可扩展性.
结论:
- 哺乳动物的大脑具有可扩展的架构,具有稳定的组成.
- 大脑型是理解大脑进化和家族遗传关系的强有力的衡量标准.
- 灵长类大脑进化是由指导选择压力塑造新皮层扩张的特征.
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