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对于维持CpXpG甲基化,需要CHROMOMETHYLASE3

A M Lindroth1, X Cao, J P Jackson

  • 1Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.

Science (New York, N.Y.)
|May 12, 2001
PubMed
概括

阿拉比多普西斯超人位沉默涉及密集的超甲基化在非正规的细胞因子. 在CHROMOMETHYLASE3 (CMT3) 中的功能丧失突变减少了这种甲基化,重新激活了基因表达并揭示了CMT3.

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