纤维素D模和冠心病:前性研究和元分析
J Danesh1, P Whincup, M Walker
1Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Medicine, University of Oxford, Oxford.
Circulation
|May 23, 2001
概括
血凝块分解的标志物纤维素D-二聚体水平升高与男性冠状动脉心脏病 (CHD) 的风险增加有关. 需要进一步的研究来确认这种联系是否具有因果关系.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 在一般人群中,轻微升高的纤维素D-二次体水平对冠心病 (CHD) 风险的临床意义尚不清楚.
- 纤维素D-模是循环生物标志物,反映纤维素循环和凝块分解.
研究的目的:
- 为了研究基线血清纤维素D-二次度和在大量男性队列中发展心脏病的风险之间的关联.
- 通过对现有的相关研究进行元分析,将这些发现置于背景中.
主要方法:
- 在630名心血管疾病病例和1269名对照患者的基线血液样本中测量了血清D-二聚体抗原水平,这是在5661名男性的前性队列中进行了16年的跟踪.
- 统计分析包括后勤回归与年龄,城市,吸烟,其他心血管风险因素和社会经济地位的调整.
- 进行了对先前研究的元分析.
主要成果:
- 基线纤维素D-二次体最高三位数的男性与最低三位数 (OR 1.67,95% CI 1.31-2.13) 的男性相比,心血管疾病的几率增加了1.67倍.
- 这种关联在进一步调整后仍然显著 (OR 1.79,95% CI 1.36-2.36).
- 纤维素D-二聚体水平与C-反应蛋白和血清粉样蛋白A蛋白有强烈的正相关性,但与传统的心脏病风险因素 (如脂质或血压) 没有相关性.
结论:
- 循环中的纤维素D-二次体水平与冠心病风险之间存在潜在的关联.
- 需要进一步调查以确定这种关系的因果关系.
相关概念视频
Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...


