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相关概念视频

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...

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相关实验视频

Updated: May 11, 2026

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics
10:31

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

Published on: October 6, 2016

梅介导了Drosophila中Ets转录因子的MAP激酶酸化.

D A Baker1, B Mille-Baker, S M Wainwright

  • 1Cell Signalling Unit, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. d.baker@ic.ac.uk

Nature
|May 18, 2001
PubMed
概括
此摘要是机器生成的。

一种新的蛋白质,Mae,在Ras/mitogen激活蛋白激酶 (MAPK) 途径中起到关键作用,通过调节像Yan这样的转录因子来控制细胞过程. 这一发现对于理解细胞信号传递和发育至关重要.

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Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
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Spatial and Temporal Analysis of Active ERK in the C. elegans Germline

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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

相关实验视频

Last Updated: May 11, 2026

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics
10:31

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

Published on: October 6, 2016

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
08:40

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline

Published on: November 29, 2016

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

科学领域:

  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 拉斯/甲基因激活蛋白激酶 (MAPK) 级联是调节细胞分裂,分化,运动和死亡的基本信号通路.
  • MAPK将细胞外信号传递到细胞核,通过酸化调节转录因子活性.

研究的目的:

  • 识别和描述MAPK信号传导通路的新组件.
  • 阐明一个新发现的蛋白质Mae (Ets活动调节器) 在将MAPK信号与转录因子联系起来的作用.

主要方法:

  • 梅蛋白的克隆和表征.
  • 调查Mae,MAPK和转录因子Yan和尖端-P2.0之间的相互作用.
  • 评估Mae在Drosophila发育和表皮生长因子受体信号传递中的体内功能.

主要成果:

  • 梅直接将MAPK途径与转录因子联系起来,特别是调节Drosophila的Yan蛋白在Ser 127的酸化.
  • 由Mae调解的MAPK对的酸化,取消了其转录抑制活动.
  • 梅还调节了转录激活剂P2.2的活性.
  • 梅叶对于虫的发育和生存能力以及表皮生长因子受体信号传递在体内至关重要.

结论:

  • 梅作为一个关键的信号中间体,将MAPK路径与特定的转录因子基质结合起来.
  • 这种机制通过确保下游目标的适当监管来提高MAPK信号特异性.
  • 梅在Drosophila的发育过程和信号转导中发挥着至关重要的作用.