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降低血管硬化是否完全解释了老年,身体活跃的男性的心血管巴罗反射功能?
B E Hunt1, W B Farquhar, J A Taylor
1Laboratory for Cardiovascular Research, Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, MA 02131, USA. hunt@mail.hrca.harvard.edu
Circulation
|May 23, 2001
概括
随着年龄的增长,心血管巴罗反射能力的降低与血管和神经缺陷有关. 身体活动有助于维持神经管控制,减轻了老年人的这些衰退.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能自主神经系统功能
- 衰老的研究研究.
背景情况:
- 心血管巴洛反射增益对于维持血压平衡至关重要.
- 与年龄相关的巴罗反射功能的下降与心血管风险增加有关.
- 了解巴罗反射增益的组成部分对于有针对性的干预是必不可少的.
研究的目的:
- 测量心血管巴罗反射增益及其血管机械和神经元件.
- 调查衰老和体力活动对这些组成部分的影响.
- 为了区分机械和神经转导对巴罗反射增益的贡献.
主要方法:
- 开发了一种新的方法来评估在巴罗反射参与期间的心跳对心跳动脉直径.
- 测量了机械传导 (直径/压力),神经传导 (R-R 间隔/直径) 和集成的心血管巴罗反射增益 (R-R 间隔/压力).
- 在未受过训练的年轻男性,未受过训练的老年男性和身体活跃的老年男性中比较了这些措施.
主要成果:
- 与未经训练的年轻男性相比,未经训练的老年男性的综合心血管脉反射增益明显较低.
- 这种下降归因于机械和神经传导的缺陷.
- 身体活跃的老年男性表现出与年轻男性相比的心血管巴罗反射增强,与未经训练的老年男性相比,机械和神经转导的改善.
- 神经转导显示,集成增益的预测权重比机械转导更大.
结论:
- 随着年龄的增长,心血管巴罗反射能力的降低是由于血管机械和神经缺陷造成的.
- 长期的体力活动可以减轻与年龄相关的心血管巴罗反射增长的下降.
- 身体活动主要保护神经管控制,这是巴罗反射功能的关键组成部分.
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