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G20210A 具有或没有血管学记录的冠状动脉疾病的受试者中的前列红素基因多态和前列红素活性
C Russo1, D Girelli, O Olivieri
1Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy. carlarusso@katamail.com
G20210A的前激素突变与冠状动脉疾病 (CAD) 或心脏病发作没有直接联系. 然而,受突变影响的高质血栓活性与CAD独立相关.
科学领域:
- 心血管遗传学 心血管遗传学
- 血栓形成的研究研究
背景情况:
- G20210A的前列血突变与前列血水平升高和静脉血栓形成风险增加有关.
- 它与动脉疾病,特别是冠状动脉疾病 (CAD) 的关联仍在争论中.
研究的目的:
- 调查G20210A前列腺激素突变的患病率及其对与CAD相关的前列腺激素活性的影响.
- 为了确定前列血水平是否是CAD的独立风险因素.
主要方法:
- 研究了660人,436人患有血管学确认的CAD和224人对照.
- 评估了G20210A突变载体状态,并测量了前列血活性.
- 利用后勤回归来分析前热血素活性和CAD之间的关联.
主要成果:
- G20210A突变异性观察到5.3%的CAD患者与3.1%的对照组 (P=0.21) 相比.
- 该G20210A等位基因显著增加了前热血素活性 (153.2%对122.2%,P<0.001).
- 与对照组相比,在CAD患者 (132.8%),发现较高的前原蛋白活性 (123.3%,P<0.005),并且与CAD独立相关 (aOR1.86).
结论:
- 而G20210A原基突变本身与血管学记录的CAD或心肌梗塞没有显著的关联.
- 受到G20210A突变影响的高质血栓活性与CAD独立相关.
- 在这个队列中,前热血素活性没有预测以前的心肌梗塞.
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