冲动性选择在老鼠中是由于核的病变引起的,核的核心是 accumbens 核
R N Cardinal1, D R Pennicott, C L Sugathapala
1Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. rudolf.cardinal@pobox.com
Science (New York, N.Y.)
|May 26, 2001
概括
选择性核 accumbens 核心病变在老鼠持续诱导的冲动选择. 这表明,核心功能障碍是冲动性的关键,影响成和精神疾病.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
背景情况:
- 冲动性选择,喜欢立即的小奖励而不是更大的延迟奖励,与成和精神疾病有关.
- 冲动选择的潜在神经解剖学基础在很大程度上仍未确定.
- 了解冲动性的神经回路对于开发有效治疗方法至关重要.
研究的目的:
- 为了研究冲动选择的神经解剖学基础.
- 确定核在调节冲动性选择行为中的作用.
- 检查前带状皮质和中间前额叶皮质对冲动选择的影响.
主要方法:
- 在老鼠的核中诱导选择性病变.
- 评估这些病变对决策行为的影响,特别是冲动性选择.
- 评估前带带皮层和中带前额皮层病变对冲动选择的影响.
主要成果:
- 核心核的选择性病变导致老鼠持续的冲动选择.
- 前带带皮层的损伤没有影响冲动性选择行为.
- 对中部前额叶皮层的损伤没有改变冲动性选择.
结论:
- 核心核在底层冲动选择的神经电路中起着至关重要的作用.
- 核心核的功能障碍可能是冲动性神经病理学的重要因素.
- 这些发现为理解和潜在地治疗特征是冲动性的疾病提供了一个神经解剖学目标.
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